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KMID : 0616120090400020089
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 2 p.89 ~ p.98
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The Effects of Aristolochic Acid on Reproductive Function in Female Rats
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Park Chul-Hoon
Kwack Seung-Jun
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Abstract
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The toxicity of aristolochic acid (ArA) has attracted considerable attention since the case of nephropathy regarding diet pill preparations was reported. The present study was performed to determine the reproductive toxicity of ArA in female SD rats. ArA was administered orally to female rats at 2, 8 or 16 mg/kg b.w./day and the females were mated with untreated males and their reproductive status was determined. ArA is well known as PLA2 inhibitor, toxic effects of such a relationship are not yet clear, and in vivo study on this matter are scarce. For this study, ArA was administered to pregnant rats at 10 or 20 mg/kg b.w./day, because premating treatments were not conducted. Administration of 20 mg/kg b.w./day caused infertility or abortion. In ArA-treated groups, PGF2a productions were inhibited and apoptosis were suppressed. Collectively, this study may help to further define the roles of sPLA2 in reproductive organs and to determine the toxic mechanisms of ArA.
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KEYWORD
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Aristolochic acid, Reproductive toxicity, Phospholipase A2, Apoptosis
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